Kanna oral dosage contains the alkaloid mesembrenone which is known as an SRI (Serotonin Reuptake Inhibitor). This means it increases the amount of serotonin available in your brain, helping you to feel relaxed and at ease. This is why kanna can be helpful for anxiety and mood disorders. It also has been found to inhibit the activity of the amygdala, a part of the brain involved in emotion and fear response.

The most common way to take kanna is as a tincture. This is where the leaves are soaked in a liquid and the concentration of alkaloids is concentrated. This form of dosage allows you to take a small amount and experience effects over a longer period of time. Kanna can also be taken sublingually, which is when it is placed under the tongue. This is sometimes preferred as it avoids the first-pass metabolism by the liver and gives you a quicker effect.

“Kanna Oral Dosage: A Step-by-Step Guide to Enhancing Your Mood and Relaxation

When taking kanna orally it is recommended to start with a low dose and increase gradually. This is because of the potential for adverse effects like nausea and laxative effects, which should subside after regular use, pupil dilation and a mild headache. It is also recommended that kanna is not combined with antidepressants (SSRI, SNRI) and strong MAOIs.

Some studies have shown that kanna can help to improve cognitive flexibility and executive function, but larger trials with more varied participants are needed to prove this claim. It is also possible that kanna could slow down the onset of Alzheimer’s, as it has been shown to block an enzyme called PDE4. [43]